Thyroid hormone may have various changes of metabolism process but the severity and pathogenesis of metabolism abnormalities in hyperthyroidism, are incompletely defined despite vast studies.
To evaluate the changes of carbohydrate metabolism in hyperthyroidism, we measured the serum levels of fasting blood sugar (FBS), total protein, albumin, hemoglobin Alc(HbAlc) and fructosamine in 42 normal controls and 60 patients with
hyperthyroidism
from March 1989 to August 1991. In hyperthyroidism group, the mean values of these results are as follows: FBS 91.9±11.7 mg/dl, total protein 7.0±1.1 g/dl, albumin 4.2±0.4 g/dl, HbAlc 5.3±1.0%, and fructosamine 2.1±0.3 mol/L. In normal
control
group, those are as follows: FBS 85.3±8. mg/dl, total protein 7.8±0.3 g/dl, albumin 4.4±0.2 mg/dl, HbAlc 4.9±0.2% and fuctosamine 2.6±0.2 mol/L.
The mean values of FBS and HbAlc in hyperthyroid group are higher than those of normal controls (p<0.01) but those of serum albumin and fructosamine in hyperthyroid group are lower than those of normal control (p<0.05) with correlation each
other.
The higher level of FBS and HbAlc in hyperthyroid group compared to normal controls appeared as changes of carbohydrate metabolism. And it was revealed that fructosamine was not relable indicator of previous serum glucose concentration in
hyperthyroidism. That may be originated from the concomitant decreased level of albumin as the greatest fraction of fructosamine. (J Kor Soc Endocrinol 7:46~51, 1992).
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